Male factor infertility in human in vitro fertilization (IVF) program is being overcome by recent development of intracytoplamic sperm injection (ICSI), because it bypasses the fertilization process between sperm and oocyte. Also ICSI can be
introduced
to such non-male factors, as polycystic ovarian syndrome (PCOD), severe endometriosis, unexplained infertility with fertilization failure or poor fertilization. In the present study, we evaluated the impact of ICSI in the treatment of
aforementioned
infertility. We analyzed the patients with PCOD, severe endometriosis and unexplained infertility underwent ICSI (6, 15 and 70 cycles) and conventional IVF cycle (9, 41 and 38 cycles) from October 1994 to September 1995.
Fertilization rates of retrieved oocytes from PCOD, severe endometriosis and unexplained infertility patients in ICSI were higher than those in conventional IVF (60.7% (48/79), 54.8% (97/177), 46.9% (417/889) vs 33.3% (50/150), 44.5% (198/445),
38.9%
(164/421), respectively, p<0.05). In PCOD group, pregnancy rate per cycle in ICSI was higher than that in conventional IVF 88.1% (5/6) vs 2.2% (2/9), p<0.05). Pregnancy rate after ICSI higher than that of conventional IVF in severe endometriosis
group,
but not significantly. But in unexplained group, pregnancy rate as similar to each group.
From these results, we achieved higher fertilization and pregnancy rates in patients with PCOD and severe endometriosis by use of ICSI. W suggest that ICSI can be applied primarily in these groups.
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